20. Lan Liu, Fan Hong, Hao Liu, Xu Zhou, Shuoxing Jiang, Petr Sulc, Jianhui Jiang, Hao Yan. A localized DNA finite-state machine with temporal resolution. Science Advances. 2022, In press.
19. Aidan Tinafar, Yu Zhou, Fan Hong, Kirstie L. Swingle, Anli A. Tang, Alexander A. Green, Keith Pardee. Cell-Free Biosensors: Synthetic Biology Without Borders, Handbook of cell biosensors, Springer, 2022
18. Longlong Si,Haiqing Bai, Crystal Yuri Oh, Tian Zhang, Amanda Jiang, Fan Hong, Yongxin Ye, Tristan X Jordan, James Logue, Marisa McGrath, Chaitra Belgur, Atiq Nurani, Wuji Cao, Rani K Powers, Rachelle Prantil-Baun, Steven P Gygi, Matthew Frieman, Benjamin R tenOever, Donald Elliot Ingber. Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity. bioRxiv,2021
17. Hao Liu, Fan Hong, Francesca Smith, John Geortz, Thomas Ouldrige, Molly M. Stevens, Hao Yan, Petr Sulc, Kinetics of RNA and RNA:DNA Hybrid Strand Displacement , ACS Synthetic Biology, 2021, In Press
16. Shuoxing Jiang, Nibedita Pal, Fan Hong, Nour Eddine Fahmi, Huiyu Hu, Matthew Vrbanac, Hao Yan, Nils G. Walter, Yan Liu, Regulating DNA Self-Assembly Dynamics with Controlled Nucleation, ACS Nano, 2021, 15, 5384-5396
15. Youngeun Kim, Adam B Yaseen, Jocelyn Y Kishi, Fan Hong, Sinem K Saka, Kuanwei Sheng, Nikhil Gopalkrishnan, Thomas E Schaus, Peng Yin, Single-strand RPA for rapid and sensitive detection of SARS-CoV-2 RNA, biorxiv
14. Fan Hong, John Shreck, Petr Sulc, Understanding DNA interactions in crowded environments with a coarse-grained model, Nucleic Acid Research, 2020, 48, 10726–10738
[preprint version]
[preprint version]
- Developed a coarse-grained model to simulate DNA interaction under cellular environment with molecular dynamics.
- Studied duplex formation, hairpin looping, strand displacement reaction with the model.
13. Fan Hong, Duo Ma, Kaiyue Wu, Lida A. Mina, Rebecca C. Luiten, Yan Liu, Hao Yan*, Alexander A. Green*.
Precise and Programmable Detection of Mutations Using Ultraspecific Riboregulators, Cell, 2020, 180, 1–15
[SNIPR code]
Precise and Programmable Detection of Mutations Using Ultraspecific Riboregulators, Cell, 2020, 180, 1–15
[SNIPR code]
- Developed a new type of RNA riboregulator that can recognize the smallest genetic changes in living cells, such as single nucleotide variation (SNV), modification in complex cellular environment and cell-free systems.
- The most specific sensor working in living cell so far.
- Developed a computational pipeline (SNIPR) to automate the design process without any prior knowledge.
- Developed a low cost, portable, paper-based, devices for virus, cfDNA mutation detection.
Highlighted by Nature Methods: Pinpointing RNA mutations.
See media coverage: ASU Now, ASU Biodesign, EurekAlert, TechnologyNetworks, ScienceDaily, Phys.org, Science Codex, GENnews, GenomeWeb, featured in Coriell Institute.
Chinese media: BioArt, 科学网，生物谷
Chinese media: BioArt, 科学网，生物谷
Featured as the Cell journal cover
12. Fan Hong, Petr Sulc. An emergent understanding of strand displacement in RNA biology, Journal of Structural Biology, 2019
11. Fan Hong, Shuoxing Jiang, Xiang Lan, Raghu Pradeep Narayanan, Petr, Sulc, Fei Zhang, Yan Liu, Hao Yan, Layered-Crossover Tiles with Precisely Tunable Angles for 2D and 3D DNA Crystal Engineering, J. Am. Chem. Soc. 2018, 140, 14670-14676.
- Developed a new set of molecular tiles for 2D and 3D DNA crystal construction
- Studied the characteristics of the layered-crossover tiles by computational simulation.
10. Shuoxing Jiang #, Fan Hong#, Huiyu Hu, Hao Yan, Yan Liu, Understanding the Elementary steps in DNA tile-based self-assembly. ACS nano, 2017, 11, 9, 9370-9381. Contributed Equally.
- A comprehensive study about the thermodynamic and kinetic features of DNA tile assemblies.
- A new energetic model has been proposed to get deeper insights about DNA tile assemblies.
9. Fan Hong, Fei Zhang, Yan Liu, Hao Yan,DNA origami: scaffolds for creating high order structures. Chemical Review, 2017, 117, 20, 12584-12640
- So far, the most comprehensive review for the design, assembly, and applications of DNA origami techniques
8. F. Zhang, F. Hong, H. Yan*, DNA Origami Tiles: Nanoscale Mazes, Nat. Nanotechnol., 2017, 12, 189-190.
7. Fan Hong, Shuoxing Jiang, Tong Wang, Yan Liu, Hao Yan, 3D Framework DNA origami structure with layered crossover motifs. Angew Chem Int Ed, 2016,55,41, 12832-12835.
- Selected as Hot paper by the editor
- Demonstrated a method of constructing DNA origami structures with 3D framework features.
Undergraduate
6. Xiaowen Ou, Fan Hong, et al, Fan Xia*, A highly sensitive and facile graphene oxide-based nucleic acid probe: Label-free detection of telomerase activity in cancer patient's urine using AIEgens, Biosensors and Bioelectronics, 2016, 89, 417-421.
5. Wei Guo #, Fan Hong#, et al, Fan Xia*. Target-Specific 3D DNA Gatekeepers for Biomimetic Nanopores, Advanced Materials, 2015, 27(12): 2090-2095. Contributed Equally.
6. Xiaowen Ou, Fan Hong, et al, Fan Xia*, A highly sensitive and facile graphene oxide-based nucleic acid probe: Label-free detection of telomerase activity in cancer patient's urine using AIEgens, Biosensors and Bioelectronics, 2016, 89, 417-421.
5. Wei Guo #, Fan Hong#, et al, Fan Xia*. Target-Specific 3D DNA Gatekeepers for Biomimetic Nanopores, Advanced Materials, 2015, 27(12): 2090-2095. Contributed Equally.
- A smart nanopore gating system with ultra-high performance based on the DNA's structural self-assembly and functionalized responsiveness.
4. Boya Wang, Ruixue Duan, Fan Hong, Fan Xia*, Real-time monitoring of enzyme-free strand displacement cascades by colorimetric assays. Nanoscale, 2015,7, 5719-5725.
3. Di Kang, Ruixue Duan, Yerpeng Tan, Fan Hong, et al, Bernard Yurke,Fan Xia*, Speeding up the self-assembly of DNA nanodevice by variety of polar solvents. Nanoscale, 2014, 6, 14153-14157.
2. Abdul Hakeem, Ruixue Duan, Boya Wang, Fan Hong, et al, Dual Stimuli-Responsive Nano-Vehicle for Controlled Drug Delivery: Mesoporous Silica Nanoparticles End-Capped with Natural Chitosan, Chemical Communications, 2014,50, 13268-13271
1. Yongmei Jia, Ruixue Duan, Fan Hong, Fan Xia*. Electrochemical Biocomputing: A New Class of Molecular-Electronic Logic Devices. Soft Matter, 2013, 9, 6571-6577
3. Di Kang, Ruixue Duan, Yerpeng Tan, Fan Hong, et al, Bernard Yurke,Fan Xia*, Speeding up the self-assembly of DNA nanodevice by variety of polar solvents. Nanoscale, 2014, 6, 14153-14157.
2. Abdul Hakeem, Ruixue Duan, Boya Wang, Fan Hong, et al, Dual Stimuli-Responsive Nano-Vehicle for Controlled Drug Delivery: Mesoporous Silica Nanoparticles End-Capped with Natural Chitosan, Chemical Communications, 2014,50, 13268-13271
1. Yongmei Jia, Ruixue Duan, Fan Hong, Fan Xia*. Electrochemical Biocomputing: A New Class of Molecular-Electronic Logic Devices. Soft Matter, 2013, 9, 6571-6577
